Prolonged QT Interval

Qualaquin is contraindicated in patients with a prolonged QT interval. One case of a fatal ventricular arrhythmia was reported in an elderly patient with a prolonged QT interval at baseline, who received quinine sulfate intravenously for P. falciparum malaria (See WARNINGS).

Glucose-6-Phosphate Dehydrogenase Deficiency

Quinine sulfate is contraindicated in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency (See WARNINGS).

Myasthenia Gravis

Quinine sulfate is contraindicated in patients with myasthenia gravis (See WARNINGS).

Hypersensitivity

Qualaquin is contraindicated in patients with known hypersensitivity to quinine. Qualaquin is also contraindicated in patients with known hypersensitivity to mefloquine or quinidine because cross-sensitivity to quinine has been documented (See PRECAUTIONS).

Qualaquin is contraindicated in patients with a history of potential hypersensitivity reactions associated with previous quinine use. These include, but are not limited to the following:

• Thrombotic thrombocytopenic purpura (TTP) or hemolytic uremic syndrome (HUS)
• Thrombocytopenia
• Blackwater fever (acute intravascular hemolysis, hemoglobinuria, and hemoglobinemia)

(See PRECAUTIONS).

Optic Neuritis

Qualaquin is contraindicated in patients with optic neuritis (See ADVERSE REACTIONS).